Dianabol, also called Methandrostenolone (en/of Methandienone), is an anabolic steroid that has been embedded in Soad Brakes in three bodybuilders and athletes. It was popular in the 1950s and 2009 during the protection period and in the “golden era of bodybuilding” in the 1960s and 1970s. Methandrostenolone waard yn e e midden fan e e jierren 1950 yntrodusearre oan ‘e wittenskiplike mienskip tri Dr. John Ziegler. It’s the American answer that lined up the testosterone fanatic with three Soviet athletes. Untwikkele three with the Ziegler team, waard it medisyn dêrnei yntrodusearre troch Ciba onder of kommersjele name Dianabol. It is the basic synthetic mûnlinge anabolic steroid used for prescription drugs.
This remedy Libben Fan Dianabol is 4.5-6 oeren. The drug has a significant estrogenic effect, and its conversion to the metabolite in other parts of the above-mentioned androgenic group of three 5-alpha-reductase enzymes is a leech. Dianabol fans have made it popular among bodybuilders and athletes who are good at cum and crawling.
The structure of Dianabol contains a 17-alpha methyl group. What makes this anabolic steroid possible for oral use is its C17 alpha alkylation, which has very noticeable effects on the body. Because of this modification, the compound is not significantly metabolized in the liver, and enough anabolic steroids enter the bloodstream to produce all the effects consistent with this class of drugs. Another structural feature of Dianabol is the double bond between the carbons in position 1 and 2. This modification gives the drug a “softer” androgenic ability than its ancestral testosterone. Because of this double bond, the drug’s affinity for androgen receptors in various tissues is lower than that of testosterone. It is thanks to this structural change that the half-life of Dianabol is higher than that of testosterone at 4.5 to 6 hours. Another benefit of this chemical modification is the drug’s low affinity for certain proteins, particularly sex hormone-binding globulin (SHBG). These globulins bind to sex hormones such as testosterone and estrogen and temporarily suppress their activity. The result of this process is the formation of an inactive protein-hormone complex that circulates in the bloodstream. It cannot bind to a receptor or be active and is essentially useless. These properties of Dianabol give it the status of being a powerful anabolic steroid. The interaction of methandrostenolone with the androgen receptor is weak compared to testosterone and other members of the steroid group, but this hormone has a stronger and more potent effect. Therefore, the assumption is that most of Dianabol’s effects are not receptor-mediated. At the same time, as you know, Dianabol’s anabolic index is 210, and testosterone index is 100. It is clear that methandrostenolone has twice the anabolic capacity, which is due to the structural modifications described above.
The effects of Dianabol
Dianabol has some limitations regarding C17 Alpha alkylation. As already mentioned, the methylation process activates the drug and ensures bioavailability when taken orally. Due to these changes, anabolic steroids are not destroyed by the liver. However, the downside of transformation is that it increases the hepatotoxicity of the drug. C17-alpha alkylation increases the resistance of anabolic steroids to degradation in the liver, and compounds with additional resistance to hepatic metabolism are more hepatotoxic. Therefore, for many consumers, the course duration should be 4-6 weeks. This maintains normal liver function and ensures organ recovery at the end of the course. As a result of taking Dianabol, an increase in liver enzymes is often observed, which returns to normal after discontinuation of the drug. Due to the risk of hepatotoxic effects, metandrostenolone is mainly used as an excipient. This medicine or any other oral anabolic steroid should not be used as monotherapy. It suppresses natural testosterone, so it leaves the body without testosterone. Users should use some form of testosterone at lower doses than hormone replacement therapy with testosterone (HRT).
Аpplication and process
In most cases, the process of using Dianabol is simple. This drug is usually used during periods of muscle building and strength gain, when bodybuilders or athletes are not too afraid of fluid retention and bloating. Therefore, the use of Dianabol is common during the “off-season” when bodybuilders are trying to achieve the above goals. The drug is usually included in the course along with injectable anabolic steroids, which are most commonly used as one of the testosterone variants (eg Testosterone Enanthate).
In most cases, Dianabol is used during the first 4-6 weeks of a strength and muscle building cycle and begins to work while users wait for the effects of a slower injection (such as testosterone enanthate). With Dianabol, even at the very beginning of the course, you can trigger the necessary mechanisms and achieve maximum results. It is very dangerous to take Dianabol for more than 4-6 weeks due to the structural properties of the C17-alpha-alkylated form, which have a negative effect on the liver (especially cholesterol levels). This is another reason why Methandrostenolone is not used as an initial cycle for more than 4-6 weeks.
Dianabol short courses are sometimes combined with the use of short, fast-acting testosterone esters. Testosterone propionate is the most commonly used. In these cases, however, the course of Dianabol remains toxic for 4-6 weeks or longer (eg testosterone propionate can often be prolonged if necessary).
Dianabol is rarely used as a fat burner, but some users use it for this purpose. This use is not recommended due to the negative effects of estrogen (fluid retention and bloating). Assessing your fitness during the diet can be difficult due to water retention in the body. There is some ambiguity about the Dianabol fat burning cycle. This is because fat loss occurs primarily through the athlete’s diet and does not depend on which anabolic steroid is used.